Substance use disorders are growing at an alarming rate in the United States. Psychopharmacologically treating addiction is already difficult in mono-diagnosis SUD patients. However, many patients with substance abuse disorders have poly-substance use disorders or have accompanying comorbid mental and physical health disorders that add to the complexity of psychopharmacological treatment.

This talk will provide an overview of the neuropharmacological basis for addiction. I will review diagnoses that are frequently co-morbid with SUD. Finally, I will address, both mono-diagnosis pharmacological approaches to substance use disorders, as well as considerations for poly-substance use, and major mental and physical comorbidities.

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